Product Details

Trainers by Asics

PRODUCT CODE

1102787

Brand

Asics have been developing sports shoes, trainers and apparel for over 60 years, introducing design philosophies that have revolutionised the world of sports. Taking an innovative approach based on scientific research and collaborations with athletes, Asics develop their product in their Japanese research and development centre, producing sports solutions and performance enhancing trainers.

LOOK AFTER ME

Treat With A Suitable Leather Protector (Not Included) And Avoid Contact With Liquids

ABOUT ME

Lining: 100% Textile, Sole: 100% Rubber, Upper: 100% Real Leather.
9090 Gel Asics In Trainers HL7W3 Black Lyte 8YYOqxR 9090 Gel Asics In Trainers HL7W3 Black Lyte 8YYOqxR 9090 Gel Asics In Trainers HL7W3 Black Lyte 8YYOqxR 9090 Gel Asics In Trainers HL7W3 Black Lyte 8YYOqxR

9090 Gel Asics In Trainers HL7W3 Black Lyte 8YYOqxR

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a canonical member of a group of dioxins which are byproducts of industrial combustion and are dangerous environmental pollutants. TCDD has been shown to cause several abnormalities in humans and wildlife, and recently, some dioxins have been found to activate platelets. However, TCDD-mediated platelet activation pathways are elusive and virtually nothing is known about TCDD activation of fish thrombocytes. To investigate TCDD effect on thrombocyte function, we tested zebrafish blood in presence of TCDD using a thrombocyte functional assay. We found that TCDD activated thrombocytes. Further experiments showed that thrombocytes of fish treated with TCDD formed both aggregates and filopodia. To investigate the mechanism of TCDD-mediated activation of thrombocytes we used inhibitors for Gq, cyclooxygenase-1, aryl hydrocarbon receptor (AHR), c-src, Akt, and ERK1/2. We found that TCDD induces AHR which activates c-src and signals the activation of Akt and ERK1/2 which are ultimately involved in generation of thromboxane A2. Furthermore, we found that ADP potentiates TCDD action, which led to the discovery that ADP itself activates AHR in the absence of TCDD. Taken together, these results resolved the pathway of TCDD activation of thrombocytes and led to the finding that ADP is an activator of AHR.


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Created with Highcharts 5.0.14 Gel Lyte Asics Trainers HL7W3 In Black 9090 2015 2016
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