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  • Margit Pavelka
    • 1
  • Jürgen Roth
    • 2
  1. 1.Center for Anatomy and Cell Biology, Department of Cell Biology and Ultrastructure ResearchMedical University of ViennaViennaAustria
  2. 2.Yonsei University Graduate School, World Class University Program, Department of Biomedical ScienceYonsei UniversitySeoulKorea
Chapter
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Abstract

Megakaryocytes are large polyploid cells present of the bone marrow, which produce the blood platelets or thrombocytes, small disk-shaped cytoplasmic fragments that circulate in the blood and are essential components of the haemostasis system. Formation and release into the blood is under the primary regulation of thrombopoietin, a glycoprotein produced in the kidney and liver. During differentiation of megakaryocytes, continued DNA replication in the presence of abortive mitosis leads to the formation of polyploid nuclei, a process called endomitosis. It has been shown that polyploidisation is connected with the suppression of stathmin, a microtubule-regulatory protein that has a major role in the formation of the mitotic spindle. Platelets are pre-formed in the cytoplasm of megakaryocytes at sites of protrusions, called proplatelets. A megakaryocyte may form 10–20 proplatelets from the tips of which the platelets are released. Maturing platelets become filled with organelles and granules, which move from the megakaryocyte cell body to the tips of the proplatelets.

References

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  2. Fuhrman B, Brook GI, and Aviram M (1992) Proteins derived from platelet alpha granules modulate the uptake of oxidized low density lipoprotein by macrophages. Biochim Biophys Acta 1127: 15 PubMedGoogle Scholar
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  5. Kaushansky K (2003) Thrombopoietin: a tool for understanding thrombopoiesis. J Thromb Haemost 1: 1587 Length Knee Black Bright Pinko Dresses Blue qEvwAPubMedBlack Prada Polyamide Leather Bag Corsaire Shoulder qxfzwxXap
  6. Mahaut-Smith MP, Thomas D, Higham AB, Usher-Smith JA, Hussain IF, Martinez-Pinna J, Skepper IN, and Mason MI (2003) Properties of the demarcation membrane system in living rat megakaryocytes. Biophys J 84: 2646 CrossRefPubMedGoogle Scholar
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Copyright information

© Springer-Verlag/Wien 2010

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Loafers by Dr Martens

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Since its creation in the 1960s, the classic Dr Martens eight eyelet boot was once an iconic footwear choice for punks, skinheads and working class rebels the world over. With technical construction that ensures each shoe or boot is durable, resistant and comfortable; Dr Martens have built a reputation on the exceptional quality of their footwear. Today, Dr Martens has retained its trademark designs but added a fresh, contemporary twist with the addition of coloured soles, soft suedes, bright colours and bold prints.

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