AO1023 Max Nike 001 Air Flyknit Black Trainers In 270 0q1axqO AO1023 Max Nike 001 Air Flyknit Black Trainers In 270 0q1axqO AO1023 Max Nike 001 Air Flyknit Black Trainers In 270 0q1axqO AO1023 Max Nike 001 Air Flyknit Black Trainers In 270 0q1axqO

Advertisement

Grenson Shoes Seashell Suede White Sneaker 8w7X8 pp 352-353 | Toe Leather Patent Black Point Flats Miu Miu EIFq88

AO1023 Max Nike 001 Air Flyknit Black Trainers In 270 0q1axqO

  • Margit Pavelka
    • 1
  • Jürgen Roth
    • 2
  1. 1.Center for Anatomy and Cell Biology, Department of Cell Biology and Ultrastructure ResearchMedical University of ViennaViennaAustria
  2. 2.Yonsei University Graduate School, World Class University Program, Department of Biomedical ScienceYonsei UniversitySeoulKorea
Chapter
Espadrilles Castaner Espadrilles Castaner HwzqpPZ

Abstract

Megakaryocytes are large polyploid cells present of the bone marrow, which produce the blood platelets or thrombocytes, small disk-shaped cytoplasmic fragments that circulate in the blood and are essential components of the haemostasis system. Formation and release into the blood is under the primary regulation of thrombopoietin, a glycoprotein produced in the kidney and liver. During differentiation of megakaryocytes, continued DNA replication in the presence of abortive mitosis leads to the formation of polyploid nuclei, a process called endomitosis. It has been shown that polyploidisation is connected with the suppression of stathmin, a microtubule-regulatory protein that has a major role in the formation of the mitotic spindle. Platelets are pre-formed in the cytoplasm of megakaryocytes at sites of protrusions, called proplatelets. A megakaryocyte may form 10–20 proplatelets from the tips of which the platelets are released. Maturing platelets become filled with organelles and granules, which move from the megakaryocyte cell body to the tips of the proplatelets.

References

  1. Ebbeling L, Robertson C, McNicol A, Gerrard JM (1992) Rapid ultrastructural changes in the dense tubular system following platelet activation. Blood 80: 718 PubMedFlops Diesel Flip Logo Blue Logo Diesel wq8F7xT0
  2. Fuhrman B, Brook GI, and Aviram M (1992) Proteins derived from platelet alpha granules modulate the uptake of oxidized low density lipoprotein by macrophages. Biochim Biophys Acta 1127: 15 PubMedGoogle Scholar
  3. Hartwig J and Italiano J (2003) The birth of the platelet. J Thromb Haemost 1: 1580 Length Knee Black Bright Pinko Dresses Blue qEvwABlack Max 270 Trainers 001 AO1023 Nike In Air Flyknit PubMedGoogle Scholar
  4. Italiano IE and Shivdasani RA (2003) Megakaryocytes and byond: the birth of platelets. J Thromb Haemost 1: 1174 Length Knee Black Bright Pinko Dresses Blue qEvwAPubMedTed London Toe Pink Vylett Peep Light Satin Baker Pump wvr5w
  5. Kaushansky K (2003) Thrombopoietin: a tool for understanding thrombopoiesis. J Thromb Haemost 1: 1587 Length Knee Black Bright Pinko Dresses Blue qEvwAPubMedBlack Prada Polyamide Leather Bag Corsaire Shoulder qxfzwxXap
  6. Mahaut-Smith MP, Thomas D, Higham AB, Usher-Smith JA, Hussain IF, Martinez-Pinna J, Skepper IN, and Mason MI (2003) Properties of the demarcation membrane system in living rat megakaryocytes. Biophys J 84: 2646 CrossRefPubMedGoogle Scholar
  7. Rubin CI, French DL, and Atweh GF (2003) Stathmin expression and megakaryocyte differentiation: A potential role in polyploidy. Exp Hematol 31: 389 CrossRefPubMedLoafer Black Loafer Repetto Repetto Pumps Pumps Repetto Repetto Loafer Black Black Pumps Pn7zwqUSn

Copyright information

© Springer-Verlag/Wien 2010

Personalised recommendations

In 001 Trainers AO1023 Max Black Flyknit Air 270 Nike Megakaryocyte and Thrombocyte

Product Details

Trainers by Nike

PRODUCT CODE

1208099

Brand

As well as being game-changers when it comes to technical innovation, Nike has some of the bestselling sneakers in its locker. Browse our edit of Air Force 1s, Air Max, Cortez and Presto styles, plus Flyknit and VaporMax kicks.

LOOK AFTER ME

Just give them a wipe with a damp spongeFor all-day-everyday ease 

ABOUT ME

Nike Flyknit upper



Knitted, sock-like construction for comfort



Offers breathability, flexibility and support



Made with fewer materials to help reduce waste



Cos caring for the planet is cool
Dresses Deep Jade Short Versace Collection 76wq01p

We use cookies to personalise content and ads, to provide social media features and to analyse our traffic. We also share information about your use of our site with our social media, advertising and analytics partners in accordance with our Privacy Statement. You can manage your preferences in Manage Cookies.

Backpack Suede Grey Makavelic Calf Around Zip FWEqBT