Product Details

Trainers by adidas

PRODUCT CODE

1163252

Brand

Influenced by the style imprint of 90s London, adidas Skateboarding reimagines courtside steez with its range of curb-surfing cuts. Made with your board in mind, expect retro-inspired T-shirts, lightweight windbreakers and thermal tops.

LOOK AFTER ME

Just give them a quick wipe with a damp cloth to cleanFor all-day-everyday ease

ABOUT ME

Suede upper



It's the real deal







Lining: 100% Textile, Sole: 100% Other materials, Upper: 100% Leather.
With Boarding adidas Trainers Matchcourt Cf Straps Skate wX55qza With Boarding adidas Trainers Matchcourt Cf Straps Skate wX55qza With Boarding adidas Trainers Matchcourt Cf Straps Skate wX55qza With Boarding adidas Trainers Matchcourt Cf Straps Skate wX55qza

With Boarding adidas Trainers Matchcourt Cf Straps Skate wX55qza

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a canonical member of a group of dioxins which are byproducts of industrial combustion and are dangerous environmental pollutants. TCDD has been shown to cause several abnormalities in humans and wildlife, and recently, some dioxins have been found to activate platelets. However, TCDD-mediated platelet activation pathways are elusive and virtually nothing is known about TCDD activation of fish thrombocytes. To investigate TCDD effect on thrombocyte function, we tested zebrafish blood in presence of TCDD using a thrombocyte functional assay. We found that TCDD activated thrombocytes. Further experiments showed that thrombocytes of fish treated with TCDD formed both aggregates and filopodia. To investigate the mechanism of TCDD-mediated activation of thrombocytes we used inhibitors for Gq, cyclooxygenase-1, aryl hydrocarbon receptor (AHR), c-src, Akt, and ERK1/2. We found that TCDD induces AHR which activates c-src and signals the activation of Akt and ERK1/2 which are ultimately involved in generation of thromboxane A2. Furthermore, we found that ADP potentiates TCDD action, which led to the discovery that ADP itself activates AHR in the absence of TCDD. Taken together, these results resolved the pathway of TCDD activation of thrombocytes and led to the finding that ADP is an activator of AHR.


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Created with Highcharts 5.0.14 Trainers With Straps adidas Skate Boarding Matchcourt Cf 2015 2016
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