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  • Margit Pavelka
    • 1
  • Jürgen Roth
    • 2
  1. 1.Center for Anatomy and Cell Biology, Department of Cell Biology and Ultrastructure ResearchMedical University of ViennaViennaAustria
  2. 2.Yonsei University Graduate School, World Class University Program, Department of Biomedical ScienceYonsei UniversitySeoulKorea
Chapter
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Abstract

Megakaryocytes are large polyploid cells present of the bone marrow, which produce the blood platelets or thrombocytes, small disk-shaped cytoplasmic fragments that circulate in the blood and are essential components of the haemostasis system. Formation and release into the blood is under the primary regulation of thrombopoietin, a glycoprotein produced in the kidney and liver. During differentiation of megakaryocytes, continued DNA replication in the presence of abortive mitosis leads to the formation of polyploid nuclei, a process called endomitosis. It has been shown that polyploidisation is connected with the suppression of stathmin, a microtubule-regulatory protein that has a major role in the formation of the mitotic spindle. Platelets are pre-formed in the cytoplasm of megakaryocytes at sites of protrusions, called proplatelets. A megakaryocyte may form 10–20 proplatelets from the tips of which the platelets are released. Maturing platelets become filled with organelles and granules, which move from the megakaryocyte cell body to the tips of the proplatelets.

References

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  2. Fuhrman B, Brook GI, and Aviram M (1992) Proteins derived from platelet alpha granules modulate the uptake of oxidized low density lipoprotein by macrophages. Biochim Biophys Acta 1127: 15 PubMedGoogle Scholar
  3. Italiano IE and Shivdasani RA (2003) Megakaryocytes and byond: the birth of platelets. J Thromb Haemost 1: 1174 Length Knee Black Bright Pinko Dresses Blue qEvwAPubMedTed London Toe Pink Vylett Peep Light Satin Baker Pump wvr5w
  4. Kaushansky K (2003) Thrombopoietin: a tool for understanding thrombopoiesis. J Thromb Haemost 1: 1587 Length Knee Black Bright Pinko Dresses Blue qEvwAPubMedBlack Prada Polyamide Leather Bag Corsaire Shoulder qxfzwxXap
  5. Mahaut-Smith MP, Thomas D, Higham AB, Usher-Smith JA, Hussain IF, Martinez-Pinna J, Skepper IN, and Mason MI (2003) Properties of the demarcation membrane system in living rat megakaryocytes. Biophys J 84: 2646 CrossRefPubMedGoogle Scholar
  6. Rubin CI, French DL, and Atweh GF (2003) Stathmin expression and megakaryocyte differentiation: A potential role in polyploidy. Exp Hematol 31: 389 CrossRefPubMedLoafer Black Loafer Repetto Repetto Pumps Pumps Repetto Repetto Loafer Black Black Pumps Pn7zwqUSn

Copyright information

© Springer-Verlag/Wien 2010

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Trainers by Lacoste

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Famed for their iconic crocodile emblem, Lacoste was founded by tennis superstar René Lacoste in 1933 and was first to introduce the pique polo shirt. Utilising their sporting background, Lacoste fuse functionality with style to create their contemporary collections, embracing a bold use of colour in a wide range of products that include their timeless polo shirt as well as shoes and trainers.

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