Whether used to hold extra pens and paper or your beauty essentials, this satin pouch is an ideal choice for the fashionista on the go. Founded by Danish designer Keld Mikkelsen in 1997, Day Birger et Mikkelsen is renowned for giving simple, clean Scandinavian silhouettes a global twist. In keeping with the label's aesthetic - defined by Mikkelsen as the sophistication of a jet setter mixed with the free spirit of a modern gypsy - each sculptural piece is artfully embellished and made to stand the test of time.
Pouch DAY Poppy Birger Mikkelsen et Pink Small zqqHSAwTn

Pouch DAY Poppy Birger Mikkelsen et Pink Small zqqHSAwTn

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a canonical member of a group of dioxins which are byproducts of industrial combustion and are dangerous environmental pollutants. TCDD has been shown to cause several abnormalities in humans and wildlife, and recently, some dioxins have been found to activate platelets. However, TCDD-mediated platelet activation pathways are elusive and virtually nothing is known about TCDD activation of fish thrombocytes. To investigate TCDD effect on thrombocyte function, we tested zebrafish blood in presence of TCDD using a thrombocyte functional assay. We found that TCDD activated thrombocytes. Further experiments showed that thrombocytes of fish treated with TCDD formed both aggregates and filopodia. To investigate the mechanism of TCDD-mediated activation of thrombocytes we used inhibitors for Gq, cyclooxygenase-1, aryl hydrocarbon receptor (AHR), c-src, Akt, and ERK1/2. We found that TCDD induces AHR which activates c-src and signals the activation of Akt and ERK1/2 which are ultimately involved in generation of thromboxane A2. Furthermore, we found that ADP potentiates TCDD action, which led to the discovery that ADP itself activates AHR in the absence of TCDD. Taken together, these results resolved the pathway of TCDD activation of thrombocytes and led to the finding that ADP is an activator of AHR.


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Created with Highcharts 5.0.14 Mikkelsen et Pink Pouch Small Birger DAY Poppy 2015 2016
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